New MRI Techniques Help Predict Neuro Outcomes

The researchers used MRI-Diffusion Tensor Imaging (DTI) and resting-state functional MRI (fMRI) to show the large-scale functional integration, or connectome, of the brain.

The study included 46 patients who had suffered a cardiac arrest, and were in a coma, and was published online in the October 2017 issue of the journal Radiology by researchers from Johns Hopkins University School of Medicine (Baltimore, MD).

The researchers assessed the functional connectivity of the brain of the patients and found that brain connectivity measurements could predict the long-term recovery potential of patients with brain damage related to a cardiac arrest they had experienced. The researchers concluded that by carrying out MRI-based measurements of the functional connections in the brain they could better predict long-term recovery for those patients who suffered from a neurological disability following a cardiac arrest. The results also showed that connectivity measures could provide early markers of long-term recovery potential in such patients.

Lead author of the study, Robert D. Stevens, MD, said, “This is game-changing information about what happens in the brains of people who suffer cardiac arrest. We realize that network architectures can be selectively disrupted in this setting. Anti-correlation was preserved in patients who recovered and abolished in those who did not. Relative preservation of this anti-correlation was the most robust signal of a favorable outcome. Connectome studies have the potential to change not only outcome prediction, but to guide treatment as well."

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Johns Hopkins University School of Medicine